In the post-Cold War world, the forces of globalization are making countries increasingly interdependent. Thus, transnational issues like global health threats will pose greater dangers to national security, economics, trade, and human development. Despite this new reality, the U.S. foreign policy infrastructure is not well equipped to take a leadership position in this field. This project will create the rationale for placing global health threats more squarely on the U.S. foreign policy agenda and identify effective strategies for doing so.