The United States and Russia are at odds on so many issues that the upcoming summit could convince their two presidents to give up on better relations and accept estrangement.

The central takeaway from Secretary of State Mike Pompeo’s Cairo speech is that the United States needs to rely more on allies to stabilize the Middle East.

A collapse of this Cold War–era INF treaty, which many believe has favored the United States, could unleash a new age of nuclear weapons competition with Russia.

Renewed tensions between the nuclear-armed rivals over Kashmir have once again put the world on high alert. 

The narrow and congested Mideast waterway has become a site of escalating U.S.-Iran tensions. Conflict in the wake of tanker attacks there could jolt global oil supplies.